%0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 2012 %@ 978-0-309-28886-6 %D 2014 %U https://nap.nationalacademies.org/catalog/18395/veterans-and-agent-orange-update-2012 %> https://nap.nationalacademies.org/catalog/18395/veterans-and-agent-orange-update-2012 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 1006 %X From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence.Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes %@ 978-0-309-07198-7 %D 2000 %U https://nap.nationalacademies.org/catalog/9982/veterans-and-agent-orange-herbicidedioxin-exposure-and-type-2-diabetes %> https://nap.nationalacademies.org/catalog/9982/veterans-and-agent-orange-herbicidedioxin-exposure-and-type-2-diabetes %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 76 %X In response to the concerns voiced by Vietnam veterans and their families, Congress called upon the National Academy of Sciences (NAS) to review the scientific evidence on the possible health effects of exposure to Agent Orange and other herbicides. This call resulted in the creation of the first NAS Institute of Medicine Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides in 1992. The committee published its initial findings in the 1994 report Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam. This report is the result of a 1999 request from the Department of Veterans Affairs (DVA) under the aegis of the Veterans and Agent Orange research program. Specifically, DVA asked the committee to examine evidence regarding the association, if any, between Type 2 diabetes and exposure to dioxin and other chemical compounds in herbicides used in Vietnam. Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes reviews the scientific evidence regarding the association, if any, between Type 2 diabetes1 and exposure to dioxin2 and other chemical compounds in herbicides used in Vietnam. This report examines, to the extent that available data permitted meaningful determinations, (1) whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiologic methods used to detect the association; (2) the increased risk of the disease among those exposed to herbicides during Vietnam service; and (3) whether there is a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 1996 %@ 978-0-309-05487-4 %D 1996 %U https://nap.nationalacademies.org/catalog/5203/veterans-and-agent-orange-update-1996 %> https://nap.nationalacademies.org/catalog/5203/veterans-and-agent-orange-update-1996 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 331 %X This book updates and evaluates the available scientific evidence regarding statistical associations between diseases and exposure to dioxin and other chemical compounds in herbicides used in Vietnam, focusing on new scientific studies and literature published since the release of Veterans and Agent Orange (1994). The update gives special attention to the relationship between exposure to herbicides and the development of birth defects and transient peripheral neuropathy, as well as the relationship between exposure to herbicides and the subsequent development of prostate, hepatobiliary, nasopharyngeal, and other cancers. The book also explores the relationship between the length of time since first exposure and the possible risk of cancer development. It reviews and summarizes the strength of scientific evidence concerning the association between herbicide use in Vietnam and each disease suspected to be associated with such exposure. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 1998 %@ 978-0-309-06326-5 %D 1999 %U https://nap.nationalacademies.org/catalog/6415/veterans-and-agent-orange-update-1998 %> https://nap.nationalacademies.org/catalog/6415/veterans-and-agent-orange-update-1998 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 624 %X Third in a series of six congressionally mandated studies occurring biennially, this book is an updated review and evaluation of the available scientific evidence regarding the statistical association between exposure to herbicides used in Vietnam and various adverse health outcomes suspected to be linked with such exposures. As part of the review, the committee convened a workshop at which issues surrounding the reanalysis and the combination of existing data on the health effects of herbicide and dioxin exposure were addressed. This book builds upon the information developed by the IOM committees responsible for the 1994 original report, Veterans and Agent Orange, and Veterans and Agent Orange: Update 1996, but will focus on scientific studies and other information developed since the release of these reports. The two previous volumes have noted that sufficient evidence exists to link soft tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, and chloracne with exposure. The books also noted that there is "limited or suggestive" evidence to show an association with exposure and a neurological disorder in veterans and with the congenital birth defect spina bifida in veterans' children. This volume will be critically important to both policymakers and physicians in the federal government, Vietnam veterans and their families, veterans organizations, researchers, and health professionals. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 2002 %@ 978-0-309-08616-5 %D 2003 %U https://nap.nationalacademies.org/catalog/10603/veterans-and-agent-orange-update-2002 %> https://nap.nationalacademies.org/catalog/10603/veterans-and-agent-orange-update-2002 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 638 %X This book updates and evaluates the available scientific evidence regarding statistical associations between diseases and exposure to dioxin and other chemical compounds in herbicides used in Vietnam, focusing on new scientific studies and literature. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 2004 %@ 978-0-309-09598-3 %D 2005 %U https://nap.nationalacademies.org/catalog/11242/veterans-and-agent-orange-update-2004 %> https://nap.nationalacademies.org/catalog/11242/veterans-and-agent-orange-update-2004 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 680 %X Sixth in a series of congressionally mandated studies, this book is an updated review and evaluation of the available evidence regarding the statistical assoication between exposure to herbicides used in Vietnam and various adverse health outcomes suspected to be linked with such exposure. This book builds upon the information contained in the earlier books in the series: Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam (1994) Veterans and Agent Orange: Update 1996 Veterans and Agent Orange: Update 1998 Veterans and Agent Orange: Update 2000 Veterans and Agent Orange: Update 2002 Veterans and Agent Orange: Herbicides and Dioxin Exposure and Type 2 Diabetes (2000) Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans (2002) Veterans and Agent Orange: Update 2004 focuses primarily on scientific studies and other information developed since the release of these earlier books. The previous volumes have noted that sufficient evidence exists to link chronic lymphocytic leukemia, soft-tissue sarcoma, non-Hodgkin’s lymphoma, Hodgkin’s disease, and chloracne with exposure. The books also noted that there is “limited or suggestive” evidence of an association between exposure and respiratory cancers, prostate cancer, multiple myeloma, the metabolic disorder porphyria cutanea tarda, early-onset transient peripheral neuropathies, Type 2 diabetes, and the congenital birth defect spinal bifida in veterans’ children. This volume will be critically important to both policymakers and physicians in the federal government, Vietnam veterans and their families, veterans’ organizations, researchers, and health professionals. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 2000 %@ 978-0-309-07552-7 %D 2001 %U https://nap.nationalacademies.org/catalog/10098/veterans-and-agent-orange-update-2000 %> https://nap.nationalacademies.org/catalog/10098/veterans-and-agent-orange-update-2000 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 622 %X Veterans and Agent Orange: Update 2000 examines the state of the scientific evidence regarding associations between diseases and exposure to dioxin and other chemical compounds in herbicides used in Vietnam. It is the fourth in a series of comprehensive reviews of epidemiologic and toxicologic studies of the agents used as defoliants during the Vietnam War. Over forty health outcomes in veterans and their children are addressed. Among the report's conclusions is that there is sufficient evidence of a link between exposure and the development of soft-tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, and chloracne in veterans. Additionally, it found that scientific studies offer "limited or suggestive" evidence of an association with other diseases in veterans—including Type 2 diabetes, respiratory cancers, prostate cancer, multiple myeloma and some forms of transient peripheral neuropathy—as well as the congenital birth defect spina bifida in veterans' children. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam %@ 978-0-309-07529-9 %D 1994 %U https://nap.nationalacademies.org/catalog/2141/veterans-and-agent-orange-health-effects-of-herbicides-used-in %> https://nap.nationalacademies.org/catalog/2141/veterans-and-agent-orange-health-effects-of-herbicides-used-in %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 832 %X Have U.S. military personnel experienced health problems from being exposed to Agent Orange, its dioxin contaminants, and other herbicides used in Vietnam? This definitive volume summarizes the strength of the evidence associating exposure during Vietnam service with cancer and other health effects and presents conclusions from an expert panel. Veterans and Agent Orange provides a historical review of the issue, examines studies of populations, in addition to Vietnam veterans, environmentally and occupationally exposed to herbicides and dioxin, and discusses problems in study methodology. The core of the book presents: What is known about the toxicology of the herbicides used in greatest quantities in Vietnam. What is known about assessing exposure to herbicides and dioxin. What can be determined from the wide range of epidemiological studies conducted by different authorities. What is known about the relationship between exposure to herbicides and dioxin, and cancer, reproductive effects, neurobehavioral disorders, and other health effects. The book describes research areas of continuing concern and offers recommendations for further research on the health effects of Agent Orange exposure among Vietnam veterans. This volume will be critically important to both policymakers and physicians in the federal government, Vietnam veterans and their families, veterans organizations, researchers, and health professionals. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans %@ 978-0-309-08338-6 %D 2002 %U https://nap.nationalacademies.org/catalog/10309/veterans-and-agent-orange-herbicidedioxin-exposure-and-acute-myelogenous-leukemia %> https://nap.nationalacademies.org/catalog/10309/veterans-and-agent-orange-herbicidedioxin-exposure-and-acute-myelogenous-leukemia %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 42 %X In 2001, in response to a request by the U.S. Department of Veterans Affairs (DVA), the Institute of Medicine (IOM) called together a committee to conduct a review of the scientific evidence regarding the association between exposure to dioxin and other chemical compounds in herbicides used in Vietnam and acute myelogenous leukemia in the offspring of Vietnam veterans. Based on the scientific evidence reviewed in this report, the committee finds there is inadequate or insufficient evidence to determine if an association exists between exposure to the herbicides used in Vietnam or their contaminants and acute myelogenous leukemia (AML) in the children of Vietnam veterans. This is a change in classification from the recent Veterans and Agent Orange: Update 2000 report, which found limited/suggestive evidence for such an association. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 1996: Summary and Research Highlights %D 1997 %U https://nap.nationalacademies.org/catalog/9079/veterans-and-agent-orange-update-1996-summary-and-research-highlights %> https://nap.nationalacademies.org/catalog/9079/veterans-and-agent-orange-update-1996-summary-and-research-highlights %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 56 %0 Book %A Institute of Medicine %T The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans %@ 978-0-309-11449-3 %D 2008 %U https://nap.nationalacademies.org/catalog/12059/the-utility-of-proximity-based-herbicide-exposure-assessment-in-epidemiologic-studies-of-vietnam-veterans %> https://nap.nationalacademies.org/catalog/12059/the-utility-of-proximity-based-herbicide-exposure-assessment-in-epidemiologic-studies-of-vietnam-veterans %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 160 %X A fundamental challenge in past studies evaluating whether health problems experienced by Vietnam veterans might be linked to wartime use of Agent Orange or other herbicides has been a lack of information about the veterans' level of exposure to these herbicides. To address that problem, researchers developed a model to assess the opportunity for herbicide exposure among these veterans. The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans presents the conclusions and recommendations of an Institute of Medicine committee (IOM) that was convened to provide guidance to the Department of Veterans Affairs (VA) about the best use of a model to characterize exposure to the troops based on their proximity to herbicide spraying in Vietnam. This book's assessment is guided by four primary considerations: to be clear about what the assessment model does and does not claim to do; to gain understanding of the strengths and limitations of data on herbicide spraying, troop locations, and health outcomes; to consider whether the model locates spraying and troops accurately to consider the potential contributions and pitfalls of using it in epidemiologic studies. Of particular interest in these deliberations were the degree to which exposure classification might be improved if the model were to be used, and the appropriate interpretation of the results of any such studies. In light of the questions that remain concerning herbicide exposure and health among Vietnam veterans and the array of evidence that has thus far been brought to bear on that issue, The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans concludes that the application of this model offers a constructive approach to extending knowledge about the effects of herbicides on the health of these veterans and merits the initial steps recommended in our report. %0 Book %A Institute of Medicine %A National Academies of Sciences, Engineering, and Medicine %T Veterans and Agent Orange: Update 2014 %@ 978-0-309-38066-9 %D 2016 %U https://nap.nationalacademies.org/catalog/21845/veterans-and-agent-orange-update-2014 %> https://nap.nationalacademies.org/catalog/21845/veterans-and-agent-orange-update-2014 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 1114 %X From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 2014 is a cumulative report of the series thus far. %0 Book %A Institute of Medicine %E Longnecker, David E. %E Manning, Frederick J. %E Worth, Melvin H., Jr. %T Review of NASA's Longitudinal Study of Astronaut Health %@ 978-0-309-09148-0 %D 2004 %U https://nap.nationalacademies.org/catalog/10903/review-of-nasas-longitudinal-study-of-astronaut-health %> https://nap.nationalacademies.org/catalog/10903/review-of-nasas-longitudinal-study-of-astronaut-health %I The National Academies Press %C Washington, DC %G English %K Space and Aeronautics %P 93 %X As part of its ongoing commitment to the nation's space program, NASA's medical leadership asked the Institute of Medicine (IOM) to review specific aspects of the scientific basis, policies, and procedures associated with the Longitudinal Study of Astronaut Health (LSAH). NASA created the LSAH in 1992 to address a variety of issues, including both the health of astronauts during space flight and the longer-term health issues that might be associated with space flight and flight training. %0 Book %A Institute of Medicine %T Disposition of the Air Force Health Study %@ 978-0-309-10099-1 %D 2006 %U https://nap.nationalacademies.org/catalog/11590/disposition-of-the-air-force-health-study %> https://nap.nationalacademies.org/catalog/11590/disposition-of-the-air-force-health-study %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %K Conflict and Security Issues %P 276 %X The Vietnam War was fought in a jungle environment that provided cover to the enemy and made battlefield observations difficult, so military strategists used herbicides to remove foliage along key roads and waterways, defoliate areas surrounding enemy bases and supply and communications routes, and improve visibility in heavily canopied forests. The last three decades have seen an ongoing debate about the effects of this military use of herbicides and the potential adverse long-term health effects on those who may have been exposed to these herbicides. In response to these concerns, the Air Force Health Study (AFHS) was created to investigate the potential relationship between the herbicides used and the health problems of those exposed. Disposition of the Air Force Health Study assesses the scientific merit of the AFHS operations and procedures, and makes recommendations for improvement. %0 Book %A Institute of Medicine %T Veterans and Agent Orange: Update 2010 %@ 978-0-309-21447-6 %D 2012 %U https://nap.nationalacademies.org/catalog/13166/veterans-and-agent-orange-update-2010 %> https://nap.nationalacademies.org/catalog/13166/veterans-and-agent-orange-update-2010 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 836 %X Because of continuing uncertainty about the long-term health effects of the sprayed herbicides on Vietnam veterans, Congress passed the Agent Orange Act of 1991. The legislation directed the Secretary of Veterans Affairs (VA) to request the Institite of Medicine to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange and other herbicides used in Vietnam to be followed by biennial updates. The 2010 update recommends further research of links between Vietnam service and specific health outcomes, most importantly COPD, tonsil cancer, melanoma, brain cancer, Alzheimer's disease, and paternally transmitted effects to offspring. %0 Book %A Institute of Medicine %E Samet, Jonathan M. %E Bodurow, Catherine C. %T Improving the Presumptive Disability Decision-Making Process for Veterans %@ 978-0-309-10730-3 %D 2008 %U https://nap.nationalacademies.org/catalog/11908/improving-the-presumptive-disability-decision-making-process-for-veterans %> https://nap.nationalacademies.org/catalog/11908/improving-the-presumptive-disability-decision-making-process-for-veterans %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 813 %X The United States has long recognized and honored the service and sacrifices of its military and veterans. Veterans who have been injured by their service (whether their injury appears during service or afterwards) are owed appropriate health care and disability compensation. For some medical conditions that develop after military service, the scientific information needed to connect the health conditions to the circumstances of service may be incomplete. When information is incomplete, Congress or the Department of Veterans Affairs (VA) may need to make a "presumption" of service connection so that a group of veterans can be appropriately compensated. The missing information may be about the specific exposures of the veterans, or there may be incomplete scientific evidence as to whether an exposure during service causes the health condition of concern. For example, when the exposures of military personnel in Vietnam to Agent Orange could not be clearly documented, a presumption was established that all those who set foot on Vietnam soil were exposed to Agent Orange. The Institute of Medicine (IOM) Committee was charged with reviewing and describing how presumptions have been made in the past and, if needed, to make recommendations for an improved scientific framework that could be used in the future for determining if a presumption should be made. The Committee was asked to consider and describe the processes of all participants in the current presumptive disability decision-making process for veterans. The Committee was not asked to offer an opinion about past presumptive decisions or to suggest specific future presumptions. The Committee heard from a range of groups that figure into this decision-making process, including past and present staffers from Congress, the VA, the IOM, veterans service organizations, and individual veterans. The Department of Defense (DoD) briefed the Committee about its current activities and plans to better track the exposures and health conditions of military personnel. The Committee further documented the current process by developing case studies around exposures and health conditions for which presumptions had been made. Improving the Presumptive Disability Decision-Making Process for Veterans explains recommendations made by the committee general methods by which scientists, as well as government and other organizations, evaluate scientific evidence in order to determine if a specific exposure causes a health condition. %0 Book %A National Research Council %T National Summit on Strategies to Manage Herbicide-Resistant Weeds: Proceedings of a Workshop %@ 978-0-309-26556-0 %D 2012 %U https://nap.nationalacademies.org/catalog/13518/national-summit-on-strategies-to-manage-herbicide-resistant-weeds-proceedings %> https://nap.nationalacademies.org/catalog/13518/national-summit-on-strategies-to-manage-herbicide-resistant-weeds-proceedings %I The National Academies Press %C Washington, DC %G English %K Agriculture %P 66 %X Preserving the efficacy of herbicides and of herbicide-resistance technology depends on awareness of the increasing resistance of weeds to herbicides used in agriculture and coordinated action to address the problem by individuals at the farm level and beyond. This summit served as a venue to bring the attention of important stakeholders to the issue and as an opportunity for experts from diverse disciplines to strategize in a coordinated way to address herbicide-resistant weeds. In convening stakeholders for this event, participants took a step toward a recommendation from the 2010 National Research Council report The Impact of Genetically Engineered Crops on Farm Sustainability in the United States that federal and state government agencies, private-sector technology developers, universities, farmer organizations, and other relevant stakeholders collaborate to document emerging weed-resistance problems and to develop cost-effective resistance-management programs and practices that preserve effective weed control. The summit provided the opportunity for stakeholders to explore the scientific basis of the emergence of herbicide resistance and to consider different perspectives on both opportunities and barriers to overcoming the problem of herbicide-resistant weeds. National Summit on Strategies to Manage Herbicide-Resistant Weeds contains a brief synopsis of key points made by each speaker at the summit. %0 Book %A National Academies of Sciences, Engineering, and Medicine %T Veterans and Agent Orange: Update 11 (2018) %@ 978-0-309-47716-1 %D 2018 %U https://nap.nationalacademies.org/catalog/25137/veterans-and-agent-orange-update-11-2018 %> https://nap.nationalacademies.org/catalog/25137/veterans-and-agent-orange-update-11-2018 %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 738 %X From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database. %0 Book %A Institute of Medicine %T Informing the Future: Critical Issues in Health, Sixth Edition %D 2011 %U https://nap.nationalacademies.org/catalog/13180/informing-the-future-critical-issues-in-health-sixth-edition %> https://nap.nationalacademies.org/catalog/13180/informing-the-future-critical-issues-in-health-sixth-edition %I The National Academies Press %C Washington, DC %G English %K Health and Medicine %P 202 %X This report illustrates the work of IOM committees in selected, major areas in recent years, followed by a description of IOM's convening and collaborative activities and fellowship programs. The last section provides a comprehensive bibliography of IOM reports published since 2007. %0 Book %A Institute of Medicine %T Informing the Future: Critical Issues in Health: Second Edition %D 2003 %U https://nap.nationalacademies.org/catalog/10853/informing-the-future-critical-issues-in-health-second-edition %> https://nap.nationalacademies.org/catalog/10853/informing-the-future-critical-issues-in-health-second-edition %I The National Academies Press %C Washington, DC %G English %K %P 172