TY - BOOK AU - National Research Council A2 - John C. Wooley A2 - Herbert S. Lin TI - Catalyzing Inquiry at the Interface of Computing and Biology SN - DO - 10.17226/11480 PY - 2005 UR - https://nap.nationalacademies.org/catalog/11480/catalyzing-inquiry-at-the-interface-of-computing-and-biology PB - The National Academies Press CY - Washington, DC LA - English KW - Biology and Life Sciences KW - Computers and Information Technology KW - Math, Chemistry, and Physics KW - Surveys and Statistics AB - The remarkable growth of both computer science and biology in recent decades has drawn attention to their areas of intersection. Both fields have much in common; they are among the most rapidly changing fields of science, they both deal with very complex systems, and they both have profound implications for science and society. To examine the potential for greater interaction between the two fields, the National Research Council undertook a study looking at ways computational science can aid the development and understanding of biology and how the biological sciences might facilitate new and more powerful computational methods. This book presents an analysis of the potential synergies at the interface of the two fields and of ways to develop new collaborations between researchers in both areas to exploit those synergies. The book provides a large sample of well-documented examples of these interactions. The study concludes that the impact of computing on biology will be deep and profound and span virtually all areas of life science research. Computational biology will ultimately become part of the biological sciences. The impact of biology on computing is less certain, but could be substantial and should be pursued. ER - TY - BOOK AU - Institute of Medicine A2 - Christine M. Micheel A2 - Sharly J. Nass A2 - Gilbert S. Omenn TI - Evolution of Translational Omics: Lessons Learned and the Path Forward SN - DO - 10.17226/13297 PY - 2012 UR - https://nap.nationalacademies.org/catalog/13297/evolution-of-translational-omics-lessons-learned-and-the-path-forward PB - The National Academies Press CY - Washington, DC LA - English KW - Biology and Life Sciences KW - Health and Medicine AB - Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials. ER -